Chimeric antigen receptors T cells (CAR-T) designates the technology that engineers receptors (usually single chain monoclonal antibody plus the sequence of T cell costimulatory domains) and expresses them on T cells. Thus constructed CAR-T cells specifically recognize and kill tumor cells, as demonstrated in vitro and in vivo.
1. Targets are not restrained by MHC, broad-spectrum indications
2. Strong affinity to the target molecules on cancer cells, efficient killing of cancer cells in
culture or in circulating system;
3. can be designed to multiple target points and more accurate, to reduce side effects of