DC-CIK治疗技术是通过采集外周全血，利用现代细胞生物技术，经分离、再分别诱导、激活、扩增DC和CIK细胞，然后将DC细胞与CIK细胞按一定比例混合共培养，制备出一种具有抗肿瘤活性的免疫细胞群，用于癌症防治和改善机体免疫功能。功能：Ø 广谱性杀伤肿瘤细胞，尤其是清除血液中的循环肿瘤细胞Ø 通过分泌多种细胞因子激活和提高自身免疫系统的能力；Ø 抑制肿瘤微转移、复发，阻抑肿瘤的发展；Ø 明显提高患者生活质量，延长患者的生存期。产品/技术优点l 细胞制品于2005年获得中国国内**的国家食品药品监督管理局临床批文；l 细胞制品CD3+/CD56+双阳率高，对癌细胞杀伤力强。DC-CIK technology platformDC-CIK, as clued by the name, is a mixture of immune effecter cells induced by cytokines and dendritic cells. The protocol includes, in the order, collection of blood from a donor, isolation of PBMC, separated induction and activation of DC and CIK from PBMC for a certain period of time, and then co-culturing of DC and CIK for another period of time until DC-CIK cell maturation for harvest. Our technology is highlighted by co-culture of dendritic cells and CIK cells, and such prepared DC-CIK cells have demonstrated to be powerful in tumor cell killing in vitro, and is expected to improve immune function and cancer prevention in vivo. Features and Function1. Nonspecific, therefore, broad-spectrum of tumor cell killing activity, clean CTCs in blood;2. Secrete a variety of cytokines upon activation; therefore, may function in immune-system regulation in vivo;3. May inhibit, in vivo, tumor cell minor metastasis, reduce recurrence, and development; 4. Improve cancer patients’ living quality, elongate patients’ survival term.Highlights in our technology/products 1. Co-culturing DC and CIK cells to render DC-CIK with high CD3 / CD56 double-positive ratio in cell prepration, thus possessing powerful killing to cancer cells2. The only cell products in China approved for clinical trial by State Food and Drug Administration
自然杀伤细胞(Natural Killer Cell，NK)是机体重要的免疫细胞，来源于骨髓淋巴样干细胞，发育成熟依赖于骨髓和胸腺微环境，主要分布于外周血和脾，不表达特异性抗原识别受体，目前临床将TCRˉ、mlgˉ、CD56+、CD16+淋巴细胞鉴定为NK细胞。NK细胞可用于癌症防治和改善机体免疫功能。功能 广谱性杀伤肿瘤细胞，尤其是清除血液中的循环肿瘤细胞； 通过分泌多种细胞因子激活和提高自身免疫系统的能力； 抑制肿瘤微转移、复发，阻抑肿瘤的发展； 明显提高癌症患者生活质量，延长患者的生存期。产品/技术优点 在NK细胞培养过程中，不使用人肿瘤细胞作为滋（饲）养细胞，因此安全； NK细胞制品纯度高、活性高，效果好。NK cells platform Natural Killer Cells (NK) are important immune cells in our body. They are derived from bone marrow lymphoid stem cells, fully developed by spinal marrow and thymus microenvironment, and mainly distributed in peripheral blood and spleen. It does not express specific antigen recognition receptors. Currently, TCR ˉ, mlg ˉ, CD56 +, CD16 + lymphocytes are identified as NK cells clinically. NK cells can be used for cancer prevention, be of potential for cancer treament, and improvement of immune function.Features and functions1. Nonspecific, therefore, broad-spectrum of tumor cell killing activity; 2. Secrete a variety of cytokines upon activation, therefore, may function in immune-system adjustment in vivo;3. May inhibit, in vivo, tumor micro metastasis, reduce recurrence and development; 4. Improve cancer patients’ living quality, elongate patients’ survival term.Highlights in our technology/products 1. Our protocol does not use human tumor cells or transformed cells as trophoblastic cells in NK cell culturing, so it is safe;2. Our preparations consist of high purity, high activity of NK cells, and therefore highly effective in anti-cancer.