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肿瘤抗原肽技术平台
 

肿瘤抗原肽是新一类肿瘤标志物。肿瘤抗原在细胞体内被分解后产生的小分子多肽,和MHC I结合形成MHC I-抗原肽复合物后,表达在癌细胞的表面。该复合物能够被CD8 T细胞识别,因此可以被利用作为癌细胞的靶分子,可用于诊断和治疗的各个方面,因此鉴定癌细胞肿瘤抗原肽具有重要的意义。我们发展出了一套综合了免疫-生物化学化/生物物理-生物信息学方法来鉴定肿瘤抗原肽的技术平台。细胞学试验表明,鉴定出来的抗原肽能诱导出高度特异的肿瘤杀伤作用。

技术特点

l  自主知识产权,已授权。(专利号:201310439062.2);

l  该方法得到的抗原肽是直接经细胞处理加工的抗原肽,真实有效;

l  抗原肽确定后可刺激CD8T细胞产生有肿瘤杀伤功能的CTL,可用于细胞治疗;

l  抗原肽所对应抗原可作为肿瘤标志物,用于肿瘤诊断试剂的研发(抗体诊断、PCR诊断);

l  肿瘤新抗原疫苗的研发。


Tumor antigen peptide identification platform

    Tumor antigen peptide is a new class of tumor markers. Tumor antigens are decomposed in the cell to generate peptides, which bind to MHC-1 to form MHC-1/antigen peptide complexes, and are displayed on cancer cell surface. The complexes can be recognized by corresponding CD8 T cells, and therefore can be used as targets for diagnosis and treatment. Identification of cancer cell tumor antigen peptides is, therefore, of great importance. We have developed a technical platform that integrates immune-biochemical / biophysical-bioinformatics methods to identify tumor antigen peptides. Our studies on cultured cells have shown that the identified antigenic peptides can induce a highly specific tumor killing effect.

 

Technical features and highlights

1.    Patented technology involved (patent no. 201310439062.2);

2.    The peptides thus obtained are those naturally processed by tumor celss, therefore

       authantic and useful;

3.    The peptide(s) can be used to stimulate tumor specifc CD8 T cell for cell immunotherapy;

4.    The peptide(s) origing protein(s) can be the tumor marker(s),  of potential use in diagnoisis;

5.    Useful in anti-tumor peptide vaccine development.

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